Qingrelishi-category Chinese medicine for chronic prostatitis: a systematic review / 中华男科学杂志

<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of the Qingrelishi-category Chinese medicine (for dispelling heat and resolving dampness) in the treatment of chronic prostatitis.</p><p><b>METHODS</b>Randomized clinical trials or controlled clinical trials comparing Qingrelishi with plant america, other herbal medicine and Western medicine in the treatment of chronic prostatitis were identified by electronic and manual retrieval and analysis. The methodological quality of the included trials was assessed and Meta-analysis was performed with Revman 4. 2 software.</p><p><b>RESULTS</b>Forty-four randomized clinical trials or controlled clinical trials (n=5746) were identified. The methodological quality ranked high in three double-blind trials and the others ranked low. Meta-analysis indicated that Qingrelishi was more effective than Nankangpian( RR 1.22, 95% CI 1.10-1.35) and Prostate( RR 1.26, 95% CI 1.13-1.41) in the treatment of chronic prostatitis. Subgroup analysis revealed that Qingrelishi was more effective than Qianliekang (RR 1.32, 95% CI 1.19-1.45) and quinolones antibiotic (RR 1.34, 95% CI 1.15-1.57). There were no significant differences in efficacy either between Qingrelishi and a-receptor blocker and Puleanpian or between Qingrelishi plus quinolone antibiotics and quinolone antibiotics alone. Eighteen articles reported side effects and no serious adverse events were reported.</p><p><b>CONCLUSION</b>Qingrelishi may be effective in the treatment of chronic prostatitis. However, the evidence is not strong due to the generally low methodological quality and the variations of the herbs. More randomized clinical trials are required.</p>

The microstructure studies of penile cavernous tissue of erectile dysfunction rat models with chronic renal failure / 中华男科学杂志

<p><b>OBJECTIVE</b>To investigate the mechanism of erectile dysfunction (ED) in rat models with chronic renal failure (CRF).</p><p><b>METHODS</b>Chronic renal failure was induced by adult male Sprague-Dawley rats, which were subjected to an excisional 5/6 nephrectomy. The rats in NCRF group and CRF group were divided into three groups randomly. Injected with apomorphine(APO, 80 microg/kg), penile erections of three groups were observed and noted by the 2nd week, 4th week respectively and 6th week from the 14th day of 5/6 nephrectomy and experimental models of ED with CRF were selected; NOS activity was examined and the microstructures of penile were observed under optical microscope with computer configuration image analysis system in selected rat models.</p><p><b>RESULTS</b>Compared with the controls, the areas of smooth muscle and NOS activity in the penile cavernous tissue of ED rats with CRF decreased significantly (P < 0.01 or P < 0.05) , and collagen fibers slightly increased, and these alterations had close correlations with the duration of CRF. The</p><p><b>CONCLUSIONS</b>Penile erection is seriously affected in rats with CRF. The decreases of areas of blood sinus had no obvious changes. the number of smooth muscles and NOS activity might be the most important factors.</p>

Experimental and clinical research of "Keyouling" on treatment of condyloma acuminata / 中华实验和临床病毒学杂志

<p><b>OBJECTIVE</b>To investigate the effects of traditional Chinese medicine "Keyouling" in treatment of condyloma acuminata (CA).</p><p><b>METHODS</b>The effects of "Keyouling" at different concentrations on growth and proliferation of rabbits' prepuce epithelial cells and CA warts tissue were assessed by means of cellular primary culture and subculture, and the effects of "Keyouling" at different concentrations on the expression level of HPV6.11 DNA and expression level of HPV6.11 DNA of different area of CA patient's penis were quantitatively detected by means of FQ-PCR.</p><p><b>RESULTS</b>"Keyouling" had no effect on growth and proliferation of rabbits' prepuce cuticle cells, but it had significant inhibition on CA warts tissue cells and expression of HPV6.11 DNA. Concentrations of "Keyouling" assumed negative correlated with cell proliferation rate of CA warts tissue and expression level of HPV6.11 DNA, and also had significant inhibition on expression of HPV6.11 DNA of negative cutaneous lesion area and cutaneous lesion area of CA patients.</p><p><b>CONCLUSION</b>"Keyouling" had significant anti HPV6.11 effect, could significantly restrain growth and proliferation of CA warts tissue cells, while it had no damaging effect on normal organic cuticle cells. It was suggested that "Keyouling" was safe in clinical use and had good therapeutic effect on CA and subclinical infection.</p>

Clinical application research of feilinjian peroral liquid in the treatment of Chlamydia and Mycoplasma infectious prostatitis / 中华男科学杂志

<p><b>OBJECTIVES</b>To evaluate the validity and security of Feilinjian peroral liquid in the treatment of chlamydia trachomatis (CT), mycoplasma hominis (Mh) and Ureaplasma urealyticum (UU) infectious prostatitis.</p><p><b>METHODS</b>Two hundred and three patients of CT, Mh or UU infectious prostatitis diagnosed by strict orientation examination were randomly divided into two groups, one given feilinjian peroral liquid, and the other azithromycin perorally, for one month as treatment period.</p><p><b>RESULTS</b>The analytical results showed that 54 (42.86%) were clinically fully recovered, 32(32.39%) were significantly effective, and 13 (10.31%) were effective in feilinjian peroral liquid group, with total significantly effective rate 68.25% and total effective rate 78.57%, both obviously higher than those in the control group(50.64% and 57.14% respectively).</p><p><b>CONCLUSIONS</b>Feilinjian peroral liquid is significantly better than azithromycin in ameliorating self-conscious symptoms, symptoms scoring of patients with CT, Mh and UU infection, with little side-effects.</p>

Therapeutic mechanisms of traditional Chinese medicine for chronic prostatitis / 中华男科学杂志

Traditional Chinese medicine (TCM) has its unique therapeutic efforts on chronic prostatitis, a common disease of the adult male. This article systematically reviews several aspects below: anti-inflammation, anti-infection, anti-fibrosis, micro-circulation improvement, urodynamics improvement, immunomodulation, improvement of the pH value of prostatic fluid and percolation dynamics of prostatic drugs, adjustment of the microelement zinc, and the characteristics of TCM therapy. It also points out the gaps in recent researches and the focal points of future development.